Foye's principles of medicinal chemistry /
Principles of medicinal chemistry
edited by Thomas L. Lemke, David A. Williams ; assistant editors, Victoria F. Roche, S. William Zito [and others]
- 6th ed
- Philadelphia : Lippincott Williams & Wilkins, 2008
- xiv, 1377 pages, 8 pages of plates : illustrations (some color) ; 29 cm
Includes bibliographical references and index
Drugs affecting the cardiovascular system -- Cardiac agents: Cardiac glycosides, antianginal, and antiarrhythmic drugs / Diuretics / Angiotensin converting enzyme inhibitors, antagonists and calcium blockers / Central and peripheral sympatholytics and vasodilators / Antihyperlipoproteinemics and inhibitors of cholesterol biosynthesis / Antithrombotics, thrombolytics, coagulants, and plasma extenders / Drugs affecting the hormonal systems -- Insulin and drugs used for the treatment of diabetes / Adrenocorticoids / Thyroid function and thyroid drugs / Calcium homeostasis / Drugs affecting the immune systems -- Nonsteroidal anti-inflammatory drugs / Antihistamines and related antiallergic and antiulcer agents -- Chemotherapeutic agents -- Antibiotics and antimicrobial agents / Antiparasitic agents / Antifungal agents / Antimycobacterial agents / Cancer and chemotherapy / Antiviral agents and protease inhibitors / Disease state management -- Asthma and chronic obstructive pulmonary disease / Men' Health / Women's Health / Ahmed S. Mehanna -- Gary O. Rankin -- Marc Harrold -- David A. Williams -- Marc Harrold -- Matthias C. Lu and Thomas L. Lemke -- Robin M. Zavod, John L. Krstenansky, and Bruce L. Currie -- Duane D. Miller, Robert W. Brueggemeier and James T. Dalton -- Ali R. Banijamali -- Robin M. Zavod -- Wendel L. Nelson -- Lester A. Mitscher, Thomas L. Lemke, and Elmer J. Gentry -- Thomas L. Lemke -- Robert K. Griffith -- Thomas L. Lemke -- Victoria F. Roche -- Patrick M. Woster -- S. William Zito -- Duane D. Miller, Robert W. Brueggermeier, and James T. Dalton -- Robin M. Zavod Section 2: Chapter 26: Chapter 27: Chapter 28: Chapter 29: Chapter 30: Chapter 31: Section 3: Chapter 32: Chapter 33: Chapter 34: Chapter 35: Section 4: Chapter 36: Chapter 37: Section 5: Chapter 38: Chapter 39: Chapter 40: Chapter 41: Chapter 42: Chapter 43: Part IV: Chapter 44: Chapter 45: Chapter 46: Historical perspective of medicinal chemistry / Principles of drug discovery -- Drug discovery from natural products / Drug design and relationship of functional groups to pharmacologic activity / Molecular modeling and in Silico drug design / Receptors and drug action / Drug discovery through enzyme inhibition / Pharmaceutical biotechnology-from nucleic acids to personalized medicine / Peptide and protein drugs / Antisense therapeutic agents / Physicochemical and biopharmaceutical properties of drug substances and pharmacokinetics / Drug metabolism / U.S. drug regulation: an overview / Drug receptors affecting neurotransmission and enzymes as catalytic receptors : overview of Drug Receptors: A Perspective / Drugs affecting cholinergic neurotransmission / Adrenergic receptors and drugs affecting adrenergic neurotransmission / Serotonin receptors and drugs affecting serotonergic neurotransmission / Amino acid neurotransmitters in the central nervous system / Inhibitors of nerve conduction: local anesthetics / Phosphodiesterase inhibitors / Pharmacodynamic Agents -- Drugs affecting central nervous system -- General anesthetics / Sedative-hypnotics / Antiseizure agents / Antidepressants / Psychotherapeutic drugs: antipsychotic and anxiolytic agents / Hallucinogens, stimulants and related drugs of abuse / Opioid analgesics / Drugs used to treat neuromuscular disorders: antiparkinsonian and spasmolytic agents / John L. Neumeyer -- A. Douglas Kinghorn -- James J. Knittel and Robin M. Zavod -- Xiang-Qun (Sean) Xie -- Timothy A. Maher and David A. Johnson -- Stephen Kerr -- Ronald E. Reid and Robert D. Sindelar -- Michael Mokotoff -- Marilyn Speedie -- Sunil S. Jambhekar -- David A. Williams -- Douglas -- David J. Triggle -- E. Kim Fifer -- Robert K. Griffith -- Richard A. Glennon and Malgorzata Dukat-Glennon -- Timothy J. Maher -- Matthias C. Lu -- Kevin Dalby -- Timothy J. Maher -- William Soine -- Barbara Leduc -- David A. Williams -- Raymond G. Booth -- Richard A. Glennon -- David S. Fries -- Raymond G. Booth pt. I: Chapter 1: Chapter 2: Chapter 3: Chapter 4: Chapter 5: Chapter 6: Chapter 7: Chapter 8: Chapter 9: Chapter 10: Chapter 11: Part II: Chapter 12: Chapter 13: Chapter 14: Chapter 15: Chapter 16: Chapter 17: Part III: Section 1: Chapter 18: Chapter 19: Chapter 20: Chapter 21: Chapter 22: Chapter 23: Chapter 24: Chapter 25:
This comprehensive text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist. A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems. Also new to this edition: Clinical Significance boxes, Drug Lists at the beginning of appropriate chapters, and an eight-page color insert with detailed illustrations of drug structures. Clinical Significance boxes show students how the content in each of the chapters relates to effective pharmaceutical care. Drug Lists at the beginning of appropriate chapters are bulleted lists that provide students with a summary of the drugs covered within the chapter